Role of IL-25 in Immunity
Published: April 1, 2015 | DOI: https://doi.org/10.7860/JCDR/2015/.5814
Azar Valizadeh, Afra Khosraviavi, Layla Jafar Zadeh, Elaheh Gholami Parizad
1. PhD Student in Clinical Microbiology Research Center, Department of Microbiology, Faculty of Medicine,Ilam University of Medical Sciences, Ilam, Iran.
2. Associate Professor, Department of Immunology, Clinical Microbiology Research Center, Ilam University of Medical Sciences, Ilam, Iran.
3. PhD Student, Department of Immunology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran.
4. PhD Student in Clinical Microbiology Research Center, Department of Microbiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran.
Correspondence
Azar Valizadeh,
Clinical Microbiology Research Center, Ilam University of Medical Sciences, Ilam, Iran.
E-mail : valizadeh-a@medilam.ac.ir
IL-25 a 2o KDa protein mostly known as IL-17E, encoded by chromosome 14, and containing 117 amino acids. Cytokine IL-17 family consists of 6 members; IL-17A to IL-17F, among which IL-25 has a unique structure and function. The receptor of IL-25 (IL-17BR) is highly expressed in the main Th2 cells. IL-25 regulates the internal safety of adaptive immune responses which leads to begin allergic diseases and plays a role in stimulation of pulmonary mucosal cells and fibroblasts. IL-25 can also have some effects on production of other cytokines. For instance, production of IL-25 in human and mice or injection of IL-25 to animals has resulted in production of high concentrations of Th2 cytokines, including IL-4, IL-5, and IL-13. Pilot studies have shown that mRNA of IL-25 has a high expression in Th2 cells. However, the mechanism through which IL-25 leads to Th2 immune response is still unknown. Reaction between IL-25 and IL-17BR leads to activation of transcription factors, such as NF-KB, STAT6, GATA3, NF-ATC1, JUNNB, MAPK, and JNK. IL-25 has been used against the kidney damage in mice. A large number of researchers in various countries, including the U.S. and Taiwan, have stated that IL-25 is a strong inflammatory cytokine protein which is involved in allergic inflammations.
[
FULL TEXT ] | [ PDF]